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Nickel toxicology. 163 Primary immunoglobulin deficiency states are due to (1) B-cell defects (as in X-linked hypogammaglobu- linemia, in which functional Bruton tyrosin kinase is lacking164), (2) abnormalities of T-cell subpopulations or macrophages (as in some cases of late-onset hypogamma- globulinemia) and their soluble products,165,166 (3) defi- ciency of molecules that are responsible for intercellular signaling between T and B lymphocytes (e.

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