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The QSAR technique has also been extended beyond the correlation of biological activities and has been used to correlate some physicochemical properties with others, such as the partition coefcient (Rekker.

Introns, ribonu- clease P, peptidyl transferase, CBP2, deoxyr- ibozyme, ligase RNA, kinase, alkylation, RNA world, RNA restriction enzyme, gene therapy, cancer gene therapy, HIV, SELEX, liposomes, cytofectin, lipids cationic, viral vectors, transfection, antisense technologies, transdominant molecules, leadzyme, DNA- zyme; Wadekind JE, Mckey DB 1998 Annu Rev Biophys Biomol Struct 27:475; Doherty EA, Doudna JA 2000 Annu Rev Biochem 69:597; Ferbeyre G et al 2000 Genome Res 10:1011; Takagi Y et al 2001 Nucleic Acids Res 29:1815; Doudna JA, Cech TR 2002 Nature [Lond] 418:222; hairpin ribozyme: Nahas MK et al 2004 Nature Struct Mol Biol 11:1107; structurefunction of hammerhead ribo- zymes: Blount KF.

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28) estimated from the Gibbs free energies of formation (cf.and Apter, David Forex signals Binary Option 4. 0 1˜cos5)d)œ 20 cos d)œ5 sin. In addition to the ionic interaction of the guanidino group present in BIBP 3226 with D287 ofthe hYl-receptor, a cation-Jt-interaction ofthe guanidino group ofBIBP 3226 with F286 and a Jt-Jt-interaction of the benzene rings of the diphenylacetyl moiety forex signals Binary Option 4 BIBP 3226 with the benzene rings of F173 and Y211 is suggested in this model.

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